General Information

    • DRAMP ID

    • DRAMP00425

    • Peptide Name

    • Tn-AFP1 (Trapa natans antifungal peptide; Plant defensin)

    • Source

    • Trapa natans

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • LMCTHPLDCSN

    • Sequence Length

    • 11

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Yeast: Candida tropicalis (MIC=32 µg/ml).

    • Hemolytic Activity

      • Tn-AFP1 has no adverse effect on red blood cells at concentration of 32 μg mL−1

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • There is a disulfide bond between Cys3 and Cys9

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00425 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00425.

Physicochemical Information

    • Formula

    • C49H80N14O17S3

    • Absent Amino Acids

    • AEFGIKQRVWY

    • Common Amino Acids

    • CL

    • Mass

    • 1233.44

    • PI

    • 5.08

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 2

    • Net Charge

    • 0

    • Boman Index

    • -11.24

    • Hydrophobicity

    • 0.109

    • Aliphatic Index

    • 70.91

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 12.5

    • Polar Residues

    • 5

DRAMP00425

Comments Information

    • Function

    • Tn-AFP1 has no adverse effect on red blood cells at concentration of 32 μg/mL.

Literature Information

  • ·Literature 1

    • Title

    • Identification of an antifungal peptide from Trapa natans fruits with inhibitory effects on Candida tropicalis biofilm formation.

    • Reference

    • Peptides. 2011 Aug;32(8):1741-1747.

    • Author

    • Mandal SM, Migliolo L, Franco OL, Ghosh AK.