General Information

    • DRAMP ID

    • DRAMP01061

    • Peptide Name

    • Antifungal peptide (Cm-p1; Plants)

    • Source

    • Cenchritis muricatus (Beaded periwinkle)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SRSELIVHQR

    • Sequence Length

    • 10

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Fungi: Botrytis cinerea (MIC=20 µM), Fusarium oxysporum (MIC=20 µM), Aspergillus niger (MIC=41 µM), Candida albicans 01U (MIC=13 µM), C. albicans 38U (MIC=7 µM), C. parapsilosis (MIC=105 µM), C. neoformans strain L26 (MIC=209 µM), C. neoformans strain L30 (MIC=209 µM), Trichophyton rubrum (MIC=3 µM).

    • Hemolytic Activity

      • [Ref.22210491] At the highest evaluated dose (256 μg/mL), Cm-p1 showed no signs of toxicity against human red blood cells.

    • Cytotoxicity

      • [Ref.22210491] At the highest evaluated dose (256 μg/mL), Cm-p1 showed no signs of toxicity against RAW 264.7 cells.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free (very possibly)

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01061 helical wheel diagram

    • PDB ID

    • 2MP9 resolved by NMR.
  • 2MP9-> 

    • Predicted Structure

    • There is no predicted structure for DRAMP01061.

Physicochemical Information

    • Formula

    • C51H89N19O16

    • Absent Amino Acids

    • ACDFGKMNPTWY

    • Common Amino Acids

    • RS

    • Mass

    • 1224.39

    • PI

    • 9.34

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +2

    • Boman Index

    • -39.77

    • Hydrophobicity

    • -0.83

    • Aliphatic Index

    • 107

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP01061

Comments Information

    • Function

    • The synthetic peptide has antifungal activity. Has no antibacterial or cytotoxic activity.

Literature Information

  • ·Literature 1

    • Title

    • Functional characterization of a synthetic hydrophilic antifungal peptide derived from the marine snail Cenchritis muricatus.

    • Reference

    • Biochimie. 2012 Apr;94(4):968-974.

    • Author

    • López-Abarrategui C, Alba A, Silva ON, Reyes-Acosta O, Vasconcelos IM, Oliveira JT, Migliolo L, Costa MP, Costa CR, Silva MR, Garay HE, Dias SC, Franco OL, Otero-González AJ.