• • DRAMP ID

  • DRAMP01083

• • Peptide Name

  • Alyteserin-1b (toads, amphibians, animals)

• • Source

  • Alytes obstetricans (European midwife toad)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • GLKEIFKAGLGSLVKGIAAHVAN

• • Sequence Length

  • 23

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • SMILES

  • CC[C@@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CN)[C@H](C)CC)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(N)=O)C(C)C

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram-

• • Target Organism

  • • Gram-negative bacterium:

      Target Organism	Activity
      Escherichia coli	MIC=25 µM

• • Hemolytic Activity

  • • [Ref:19463738] LC50 = 210 μM against human erthrocytes.

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • α-Amidation

• • Nonterminal Modifications and Unusual Amino Acids

• • Stereochemistry

  • L (to be determined)

• • Structure

  • Not found

• • Structure Description

  • Not found

• • PDB ID

• Predicted Structure

• There is no predicted structure for DRAMP01083.

DRAMP01083

• • Function

  • Amtimicrobial peptide. (By similarity)

• ·Literature 1

• • Title

  • The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae).

• • Pubmed ID

  • 19463738

• • Reference

  • Peptides. 2009 Jun;30(6):1069-1073.

• • Author

  • Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC.