General Information

    • DRAMP ID

    • DRAMP01105

    • Peptide Name

    • Maximin-S4 (chain of Maximins-S type B/C; toads, amphibians, animals)

    • Source

    • Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)

    • Family

    • Belongs to the bombinin family

    • Gene

    • Not found

    • Sequence

    • RSNKGFNFMVDMIQALSK

    • Sequence Length

    • 18

    • Protein Existence

    • Protein level

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(N)=O

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • [Ref.15649437]Mycoplasma humenis (MIC=46 µM), Ureaplasma urealyticum (MIC=46 µM).

    • Hemolytic Activity

      • [Ref:15649437] Maximin S1 and S4 had no hemolytic activity.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP01105.

Physicochemical Information

    • Formula

    • C91H148N26O26S2

    • Absent Amino Acids

    • CEHPTWY

    • Common Amino Acids

    • FKMNS

    • Mass

    • 2086.45

    • PI

    • 9.99

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +2

    • Boman Index

    • -33.07

    • Hydrophobicity

    • -0.256

    • Aliphatic Index

    • 65

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP01105

Comments Information

    • Function

    • Maximin-S3 has an activity against mycoplasma but has no activity against common Gram-positive and Gram-negative bacteria nor fungi. Has no hemolytic activity. Tissue specificity

Literature Information

  • ·Literature 1

    • Title

    • Maximins S, a novel group of antimicrobial peptides from toad Bombina maxima.

    • Reference

    • Biochem Biophys Res Commun. 2005 Feb 18;327(3):945-951.

    • Author

    • Wang T, Zhang J, Shen JH, Jin Y, Lee WH, Zhang Y.