General Information

    • DRAMP ID

    • DRAMP01177

    • Peptide Name

    • Ocellatin-F1 (Fallaxin; Frogs, amphibians, animals)

    • Source

    • Leptodactylus fallax (Mountain chicken frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GVVDILKGAAKDIAGHLASKVMNKL

    • Sequence Length

    • 25

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.15544856]Gram-negative bacteria: Escherichia coli (MIC=40 µM), Pseudomonas aeruginosa (MIC=80 µM), Enterobacter cloacae (MIC=20 µM), Klebsiella pneumoniae (MIC=80 µM).

    • Hemolytic Activity

      • [Ref:15544856]HC50>200 μM hemolytic activity of fallaxin

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01177 helical wheel diagram

    • Predicted Structure

Physicochemical Information

    • Formula

    • C113H198N32O32S

    • Absent Amino Acids

    • CEFPQRTWY

    • Common Amino Acids

    • AK

    • Mass

    • 2549.07

    • PI

    • 9.53

    • Basic Residues

    • 5

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +3

    • Boman Index

    • -5.21

    • Hydrophobicity

    • 0.432

    • Aliphatic Index

    • 128.8

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP01177

DRAMP01177 chydropathy plot

Comments Information

    • Function

    • Has low hemolytic activity of fallaxin (HC50>200 µM).

Literature Information

  • ·Literature 1

    • Title

    • An antimicrobial peptide from the skin secretions of the mountain chicken frog Leptodactylus fallax (Anura:Leptodactylidae).

    • Reference

    • Regul Pept. 2005 Jan 15;124(1-3):173-178.

    • Author

    • Rollins-Smith LA, King JD, Nielsen PF, Sonnevend A, Conlon JM.