General Information
-
DRAMP ID
- DRAMP01192
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Peptide Name
- Andersonin-Y1 (Frogs, amphibians, animals)
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Source
- Odorrana andersonii (Golden crossband frog)
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Family
- Not found
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Gene
- Not found
-
Sequence
- FLPKLFAKITKKNMAHIR
-
Sequence Length
- 18
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UniProt Entry
- No entry found
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Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.2 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=3.2 µg/ml);
- Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=1.6 µg/ml);
- Yeast: Candida albicans ATCC 2002 (MIC=1.6 µg/ml).
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Hemolytic Activity
-
- [Ref:22029824]Not found
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
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N-terminal Modification
- Free
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C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP01192_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C102H170N28O21S
Absent Amino Acids
- CDEGQSVWY
Common Amino Acids
- K
Mass
- 2156.71
PI
- 11.33
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +6
-
Boman Index
- -19.38
Hydrophobicity
- -0.078
Aliphatic Index
- 97.78
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 2
DRAMP01192
Comments Information
Function
- Active against bacteria and fungi.
Literature Information
- ·Literature 1
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Title
- Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
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Pubmed ID
- 22029824
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Reference
- J Proteome Res. 2012 Jan 1;11(1):306-319.
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Author
- Yang X, Lee WH, Zhang Y.