General Information

    • DRAMP ID

    • DRAMP01197

    • Peptide Name

    • Andersonin-N1 (Frogs, amphibians, animals)

    • Source

    • Odorrana andersonii (Golden crossband frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ENMFNIKSSVESDSFWG

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.22029824]Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli ATCC 25922MIC>200 µg/ml
        Bacillus pyocyaneus CMCCB 10104 (MIC>200 µg/ml);-
      • Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>200 µg/ml);
      • Yeast: Candida albicans ATCC 2002 (MIC>200 µg/ml).

    • Hemolytic Activity

      • [Ref:22029824]Non-hemolytic activity against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01197 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01197.

Physicochemical Information

    • Formula

    • C87H125N21O30S

    • Absent Amino Acids

    • ACHLPQRTY

    • Common Amino Acids

    • S

    • Mass

    • 1977.13

    • PI

    • 4.14

    • Basic Residues

    • 1

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 5

    • Net Charge

    • -2

    • Boman Index

    • -34.23

    • Hydrophobicity

    • -0.571

    • Aliphatic Index

    • 40

    • Half Life

      • Mammalian:1 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 343.75

    • Polar Residues

    • 7

DRAMP01197

Comments Information

    • Function

    • Weakly active against bacteria and fungi and has no hemolytic activity under the test conditions.

Literature Information

  • ·Literature 1

    • Title

    • Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.

    • Reference

    • J Proteome Res. 2012 Jan 1;11(1):306-319.

    • Author

    • Yang X, Lee WH, Zhang Y.