• • DRAMP ID

  • DRAMP01208

• • Peptide Name

  • Pleurain-A1 (Pleurain A1; Frogs, amphibians, animals)

• • Source

  • Rana pleuraden (Yunnan pond frog)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • SIITMTKEAKLPQLWKQIACRLYNTC

• • Sequence Length

  • 26

• • UniProt Entry

  • A8DY01,A8DY00,A8DY02,A8DY03,A8DY04,A8DY09,A8DY10,A8DY15

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.17764786]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=60 µg/ml), Helicobacter pylori NCTC 11637 (MIC=30 µg/ml);
    • Gram-positive bacteria: Bacillus dysenteriae (MIC=120 µg/ml), Staphylococcus aureus ATCC 2592 (MIC=15 µg/ml);
    • Yeast: Candida albicans ATCC 2002 (MIC=30 µg/ml)..

• • Hemolytic Activity

  • • [Ref:17764786] It has little hemolytic activity on red blood cells even with peptide concentration up to 200 μg/ml

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Cyclization (Cys20 and Cys26)

• • Nonterminal Modifications and Unusual Amino Acids

  • Disulfide bond between Cys20 and Cys26.

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP01208_predicted_structure.pdb to download.

DRAMP01208

• • Function

  • Has little hemolytic activity on red blood cells.

• • Tissue specificity

  • Expressed by the skin dorsal glands.

• ·Literature 1

• • Title

  • A new family of antimicrobial peptides from skin secretions of Rana pleuraden

• • Pubmed ID

  • 17764786

• • Reference

  • Peptides. 2007 Oct;28(10):2069-2074.

• • Author

  • Wang X, Song Y, Li J, Liu H, Xu X, Lai R, Zhang K.