• • DRAMP ID

  • DRAMP01246

• • Peptide Name

  • Japonicin-2 (Frogs, amphibians, animals)

• • Source

  • Rana japonica (Japanese brown frog)

• • Family

  • Belongs to the frog skin active peptide family (Brevinin subfamily)

• • Gene

  • Not found

• • Sequence

  • FGLPMLSILPKALCILLKRKC

• • Sequence Length

  • 21

• • UniProt Entry

  • P83306

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • Gram-negative bacterium: Escherichia coli (MIC=12 µM);
    • Gram-positive bacterium: Staphylococcus aureus (MIC=20 µM).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Cyclization (Cys14 and Cys21)

• • Nonterminal Modifications and Unusual Amino Acids

  • Disulfide bond between Cys14 and Cys21.

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP01246_predicted_structure.pdb to download.

DRAMP01246

• • Tissue specificity

  • Expressed by the skin glands.

• ·Literature 1

• • Title

  • Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica.

• • Pubmed ID

  • 11835990

• • Reference

  • Peptides. 2002;23:419-425.

• • Author

  • Isaacson T, Soto A, Iwamuro S, Knoop FC, Conlon JM.