• • DRAMP ID

  • DRAMP01251

• • Peptide Name

  • Dybowskin-4 (Frogs, amphibians, animals)

• • Source

  • Rana dybowskii (Korea brown frog)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • VWPLGLVICKALKIC

• • Sequence Length

  • 15

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.17698251]Gram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=1.56 µg/ml), Staphylococcus aureus KCTC3881 (MIC=3.13 µg/ml), Bacillus subtilis ATCC6633 (MIC=6.25 µg/ml), Staphylococcus epidermidis ATCC12228 (MIC=6.25 µg/ml);
    • Gram-negative bacteria: Shigella dysenteriae ATCC9752 (MIC=30 µg/ml), Escherichia coli KCTC2433 (MIC=15 µg/ml), Klebsiella pneumoniae ATCC10031 (MIC=15 µg/ml);
    • Yeast: Candida albicans ATCC36232 (MIC=25 µg/ml).

• • Hemolytic Activity

  • • [Ref:17698251] It has 47.58% hemolytic activity at 100 μg/ml against human red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Cyclization (Cys9 and Cys15)

• • Nonterminal Modifications and Unusual Amino Acids

  • Disulfide bond between Cys9 and Cys15.

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP01251_predicted_structure.pdb to download.

DRAMP01251

• • Function

  • Dybowskin-4 has relatively greater hemolytic activity against human red blood cells (hRBCs).

• ·Literature 1

• • Title

  • Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii.

• • Pubmed ID

  • 17698251

• • Reference

  • Peptides 2007; 28: 1532-1539.

• • Author

  • Kim SS, Shim MS, Chung J, Lim DY, Lee BJ.