General Information

    • DRAMP ID

    • DRAMP01255

    • Peptide Name

    • Dybowskin-2CDYa (Chensinin-1; Frogs, amphibians, animals)

    • Source

    • Rana dybowskii (Dybovsky's frog) (Korean brown frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SAVGRHGRRFGLRKHRKH

    • Sequence Length

    • 18

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.19539775] Gram-negative bacterium: Escherichia coli (MIC=3 µM);
      • Gram-negative bacterium: Staphylococcus aureus (MIC=6 µM).
      • [Ref.19341344] Gram-positive bacteria: Staphylococcus aureus (MIC=14.4 µM), Bacillus cereus (MIC=14.4 µM), Streptococcus lactis (MIC=14.4 µM).

    • Hemolytic Activity

      • [Ref:19539775]HC50>300 μM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01255 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C92H155N41O20

    • Absent Amino Acids

    • CDEIMNPQTWY

    • Common Amino Acids

    • R

    • Mass

    • 2155.51

    • PI

    • 12.6

    • Basic Residues

    • 10

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +10

    • Boman Index

    • -86.51

    • Hydrophobicity

    • -1.628

    • Aliphatic Index

    • 43.33

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01255

DRAMP01255 chydropathy plot

Comments Information

    • Function

    • Antimicrobial peptide. Has activity against the Gram-positive bacteria

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii.

    • Reference

    • Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178.

    • Author

    • Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH.
  • ·Literature 2

    • Title

    • Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis.

    • Reference

    • Zoolog Sci. 2009 Mar;26(3):220-226.

    • Author

    • Shang D, Yu F, Li J, Zheng J, Zhang L, Li Y.