General Information

    • DRAMP ID

    • DRAMP01261

    • Peptide Name

    • Dermadistinctin-Q2 (DD Q2; Frogs, amphibians, animals)

    • Source

    • Phyllomedusa distincta (Monkey frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLWSKIKEAAKTAGLMAMGFVNDMV

    • Sequence Length

    • 25

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=22 µM), Enterococcus faecalis (MIC=11 µM);
      • Gram-negative bacteria: Pseudomonas aeruginosa (MIC=22 µM), Escherichia coli (MIC=5.6 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.10477123]To produce hemolysis more than 38 μM peptide concentrations was required.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01261 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C119H194N30O33S3

    • Absent Amino Acids

    • CHPQRY

    • Common Amino Acids

    • A

    • Mass

    • 2669.21

    • PI

    • 8.5

    • Basic Residues

    • 3

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +1

    • Boman Index

    • 0.47

    • Hydrophobicity

    • 0.416

    • Aliphatic Index

    • 86

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 229.17

    • Polar Residues

    • 6

DRAMP01261

DRAMP01261 chydropathy plot

Comments Information

    • Function

    • Amphibian defense peptide.

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.

    • Reference

    • Peptides. 1999;20(6):679-686.

    • Author

    • Batista CV, da Silva LR, Sebben A, Scaloni A, Ferrara L, Paiva GR, Olamendi-Portugal T, Possani LD, Bloch C Jr.