General Information

    • DRAMP ID

    • DRAMP01427

    • Peptide Name

    • Nigrocin-1-OA2 (Frogs, amphibians, animals)

    • Source

    • Odorrana andersonii (Asian frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GIFGKILGVGKKTLCELSGMC

    • Sequence Length

    • 21

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.3 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.3 µg/ml);
      • Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6.3 µg/ml);
      • Yeast: Candida albicans ATCC 2002 (MIC=3.2 µg/ml).

    • Hemolytic Activity

      • [Ref:22029824] Not found in the literature

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys15 and Cys21)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys15 and Cys21.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01427 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C95H164N24O26S3

    • Absent Amino Acids

    • ADHNPQRWY

    • Common Amino Acids

    • G

    • Mass

    • 2154.67

    • PI

    • 8.86

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +2

    • Boman Index

    • 11.8

    • Hydrophobicity

    • 0.743

    • Aliphatic Index

    • 106.67

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 6.25

    • Polar Residues

    • 9

DRAMP01427

DRAMP01427 chydropathy plot

Comments Information

    • Function

    • Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans.

Literature Information

  • ·Literature 1

    • Title

    • Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.

    • Reference

    • J Proteome Res. 2012 Jan 1;11(1):306-319.

    • Author

    • Yang X, Lee WH, Zhang Y.