General Information

    • DRAMP ID

    • DRAMP01452

    • Peptide Name

    • Esculentin-1LTa (Frogs, amphibians, animals)

    • Source

    • Hylarana latouchii (Broad-folded frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RISFKKGKGSWIKNGLIKGIKGLGKEISLDVIRTGIDIAGCKIKGEC

    • Sequence Length

    • 47

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=0.6 µM), Bacillus licheniformis X39 (MIC=10 µM), Staphylococcus carnosus KHS (MIC=1.3 µM), Rhodococcus rhodochrous X15 (MIC=0.3 µM);
      • Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=5 µM), Serratia rubidaea X01 (MIC=10 µM), Psychrobacter faecalis X29 (MIC=0.6 µM).
      • Yeast: Candida albicans ATCC2002 (MIC=80 µM).

    • Hemolytic Activity

      • [Ref.22426384] LD50>480 μM against human erythrocytes

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys41 and Cys47)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys41 and Cys47.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01452 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C225H388N64O61S2

    • Absent Amino Acids

    • HMPQY

    • Common Amino Acids

    • GIK

    • Mass

    • 5030.07

    • PI

    • 9.94

    • Basic Residues

    • 11

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 16

    • Net Charge

    • +7

    • Boman Index

    • -49.04

    • Hydrophobicity

    • -0.075

    • Aliphatic Index

    • 107.87

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 122.28

    • Polar Residues

    • 16

DRAMP01452

DRAMP01452 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii.

    • Reference

    • Biochimie. 2012 Jun;94(6):1317-1326.

    • Author

    • Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J.