General Information

    • DRAMP ID

    • DRAMP01453

    • Peptide Name

    • Esculentin-2LTa (Frogs, amphibians, animals)

    • Source

    • Hylarana latouchii (Broad-folded frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GIFSLFKAGAKFFGKHLLKQAGKAGAEHLACKATNQC

    • Sequence Length

    • 37

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=1.6 µM), Bacillus licheniformis X39 (MIC=3.2 µM), Staphylococcus carnosus KHS (MIC=3.2 µM), Rhodococcus rhodochrous X15 (MIC=0.8 µM);
      • Gram-negative bacterium: Psychrobacter faecalis X29 (MIC=1.6 µM).

    • Hemolytic Activity

      • [Ref.22426384] LD50>600 μM against human erythrocytes

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys31 and Cys37)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys31 and Cys37.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01453 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01453.

Physicochemical Information

    • Formula

    • C177H296N44O58S5

    • Absent Amino Acids

    • HPWY

    • Common Amino Acids

    • L

    • Mass

    • 4296.91

    • PI

    • 4.25

    • Basic Residues

    • 3

    • Acidic Residues

    • 7

    • Hydrophobic Residues

    • 12

    • Net Charge

    • -4

    • Boman Index

    • -46.67

    • Hydrophobicity

    • 0.097

    • Aliphatic Index

    • 105.41

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 8

DRAMP01453

DRAMP01453 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii.

    • Reference

    • Biochimie. 2012 Jun;94(6):1317-1326.

    • Author

    • Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J.