General Information

    • DRAMP ID

    • DRAMP01626

    • Peptide Name

    • Bombinin-H5 (Frogs, amphibians, animals)

    • Source

    • Bombina variegata (European frog)

    • Family

    • Belongs to the bombinin family

    • Gene

    • Not found

    • Sequence

    • IIGPVLGLVGSALGGLLKKI

    • Sequence Length

    • 20

    • Protein Existence

    • Protein level

    • SMILES

    • CC[C@@H](C)[C@H](N)C(=O)N[C@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N)=O)[C@H](C)CC)C(C)C)C(C)C)[C@H](C)CC

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.8223491]Gram-negative bacterium:
        Target OrganismActivity
        Escherichia coli D21 (MIC=5.0 µM);-
      • Gram-positive bacterium:
        Target OrganismActivity
        Staphylococcus aureus Cowan 1MIC=3.0 µM

    • Hemolytic Activity

      • [Ref:8223491]Not found

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • Mixed (2D-aIle(alloisoleucine))

    • Predicted Structure

Physicochemical Information

    • Formula

    • C91H164N22O22

    • Absent Amino Acids

    • CDEFHMNQRTWY

    • Common Amino Acids

    • GL

    • Mass

    • 1918.44

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +2

    • Boman Index

    • 39.45

    • Hydrophobicity

    • 1.525

    • Aliphatic Index

    • 190

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP01626

DRAMP01626 chydropathy plot

Comments Information

    • Function

    • Has antimicrobial activity.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • C-terminal amidation and D-amino acid.

Literature Information

  • ·Literature 1

    • Title

    • Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata.

    • Reference

    • EMBO J. 1993 Dec;12(12):4829-4832

    • Author

    • Mignogna G, Simmaco M, Kreil G, Barra D.
  • ·Literature 2

    • Title

    • Solution structure and orientation of bombinin H2 and H4 in a membrane-mimetic environment.

    • Reference

    • TO BE PUBLISHED

    • Author

    • Zangger K, Jilek A, Khatai L.