General Information

    • DRAMP ID

    • DRAMP01779

    • Peptide Name

    • Temporin-SHf (Frogs, amphibians, animals)

    • Source

    • Pelophylax saharicus (Sahara frog) (Rana saharica)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • preproTemp-SHf

    • Sequence

    • FFFLSRIFGK

    • Sequence Length

    • 10

    • Protein Existence

    • Transcript level

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(N)=O

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium:
        Target OrganismActivity
        Staphylococcus aureus (MIC=12.5 µM);-
      • Gram-negative bacterium:
        Target OrganismActivity
        Escherichia coliMIC=25-200 µM

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP01779.

Physicochemical Information

    • Formula

    • C65H92N14O12

    • Absent Amino Acids

    • ACDEHMNPQTVWY

    • Common Amino Acids

    • F

    • Mass

    • 1261.53

    • PI

    • 11

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +2

    • Boman Index

    • -1.17

    • Hydrophobicity

    • 0.99

    • Aliphatic Index

    • 78

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP01779

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Temporin-SHf, a new type of phe-rich and hydrophobic ultrashort antimicrobial peptide.

    • Reference

    • J Biol Chem. 2010 May 28;285(22):16880-16892.

    • Author

    • Abbassi F, Lequin O, Piesse C, Goasdoue N, Foulon T, Nicolas P, Ladram A.