General Information

    • DRAMP ID

    • DRAMP01789

    • Peptide Name

    • Temporin-1Va (Temporin 1Va; Frogs, amphibians, animals)

    • Source

    • Rana virgatipes (Ranidae) (Aquarana)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FLSSIGKILGNLL

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Protein level

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@H](C)CC

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.15996769]Gram-positive bacteria:
        Target OrganismActivity
        Staphylococcus aureus NCTC8325MIC=10 µM
        S. aureus (MRSA) T7/20MIC=20 µM
        S. epidermidis RP62AMIC=20 µM
        Enterococcus faecalis ATCC 29212MIC=40 µM
        Streptococcus group B HNTCC 80130 (MIC=20 µM);-
      • Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli ATCC25922MIC=40 µM
        Klebsiella pneumoniae KK3 9904MIC=80 µM
        Pseudomonas aeruginosa ATCC 27853MIC=160 µM
        Enterobacter cloacae HNTCC 53001 (MIC=40 µM);-
      • Yeast:
        Target OrganismActivity
        Candida albicans ATCC 90028MIC=160 µM

    • Hemolytic Activity

      • [Ref:15996769]LD50=120 μM against washed human erythrocytes

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP01789.

Physicochemical Information

    • Formula

    • C65H111N15O17

    • Absent Amino Acids

    • ACDEHMPQRTVWY

    • Common Amino Acids

    • L

    • Mass

    • 1374.69

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +1

    • Boman Index

    • 15.39

    • Hydrophobicity

    • 1.323

    • Aliphatic Index

    • 180

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP01789

Comments Information

    • Function

    • It also has weak hemolytic activty.

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana).

    • Reference

    • Regul Pept. 2005 Nov;131(1-3):38-45.

    • Author

    • Conlon JM, Abraham B, Sonnevend A, Jouenne T, Cosette P, Leprince J, Vaudry H, Bevier CR.