General Information

    • DRAMP ID

    • DRAMP01804

    • Peptide Name

    • Temporin-CDYb (Brevinin-1CDYb; Frogs, amphibians, animals)

    • Source

    • Rana dybowskii (Dybovsky's frog) (Korean brown frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • ILPILAPLIGGLL

    • Sequence Length

    • 13

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Swiss_Prot Entry B3VZU4]Gram-positive bacterium: Staphylococcus aureus (MIC>100 µM);
      • Gram-negative bacterium: Escherichia coli (MIC>100 µM).

    • Hemolytic Activity

      • [Ref:19539775]HC50=180 μM against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01804 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01804.

Physicochemical Information

    • Formula

    • C65H115N13O14

    • Absent Amino Acids

    • CDEFHKMNQRSTVWY

    • Common Amino Acids

    • L

    • Mass

    • 1302.71

    • PI

    • 5.52

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • 0

    • Boman Index

    • 43.05

    • Hydrophobicity

    • 2.331

    • Aliphatic Index

    • 247.69

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP01804

Comments Information

    • Function

    • Has low activity against the Gram-positive bacteria

Literature Information

  • ·Literature 1

    • Title

    • Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii.

    • Reference

    • Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):174-178.

    • Author

    • Jin LL, Li Q, Song SS, Feng K, Zhang DB, Wang QY, Chen YH.