General Information

    • DRAMP ID

    • DRAMP02458

    • Peptide Name

    • L-amino-acid oxidase (BiLAO; LAAO; LAO; snakes, reptils, animals)

    • Source

    • Bothrops insularis (Golden lancehead) (Queimada jararaca)

    • Family

    • Belongs to the flavin monoamine oxidase family (FIG1 subfamily)

    • Gene

    • Not found

    • Sequence

    • ADDKNPLEECFREDDYEGFLEIAKNGLSTTSNPKRVVIVGAGMSGLAAY

    • Sequence Length

    • 49

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antiparasitic

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02458 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02458.

Physicochemical Information

    • Formula

    • C230H361N61O78S2

    • Absent Amino Acids

    • HQW

    • Common Amino Acids

    • AEG

    • Mass

    • 5292.88

    • PI

    • 4.4

    • Basic Residues

    • 5

    • Acidic Residues

    • 9

    • Hydrophobic Residues

    • 16

    • Net Charge

    • -4

    • Boman Index

    • -85.98

    • Hydrophobicity

    • -0.378

    • Aliphatic Index

    • 75.71

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 2980

    • Absorbance 280nm

    • 62.08

    • Polar Residues

    • 16

DRAMP02458

DRAMP02458 chydropathy plot

Comments Information

    • Function

    • Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity). In addition, this protein induces apoptosis and necrosis and has inhibitory effects on rat kidney Function

    • Tissue specificity

    • Expressed by the venom gland.

Literature Information

  • ·Literature 1

    • Title

    • Purification and biological effects of L-amino acid oxidase isolated from Bothrops insularis venom.

    • Reference

    • Toxicon. 2008 Feb;51(2):199-207.

    • Author

    • Braga MD, Martins AM, Amora DN, de Menezes DB, Toyama MH, Toyama DO, Marangoni S, Alves CD, Barbosa PS, de Sousa Alves R, Fonteles MC, Monteiro HS.