• • DRAMP ID

  • DRAMP02478

• • Peptide Name

  • L-amino-acid oxidase (Bm-LAO; LAAO; LAO; Snakes, reptiles, animals)

• • Source

  • Bothropoides matogrossensis (Pitviper) (Bothrops neuwiedimatogrossensis)

• • Family

  • Belongs to the flavin monoamine oxidase family (FIG1 subfamily)

• • Gene

  • Not found

• • Sequence

  • IKFEPPLPPKKAHKKFWEDDGIYYPPNHNFP

• • Sequence Length

  • 31

• • UniProt Entry

  • B3EWI9

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiparasitic

• • Target Organism

  • • Gram-positive bacteria:

      Target Organism	Activity
      Bacillus subtilis strain ATCC 6633	MIC=32 µM
      Enterococcus faecalis strain ATCC 12953	MIC=32 µM
      Staphylococcus aureus strain ATCC 29213	MIC=32 µM
      Streptococcus pyogenes strain ATCC 19615 (MIC=8 µM);	-

    • Gram-negative bacteria:

      Target Organism	Activity
      Escherichia coli strain ATCC 8739	MIC=4 µM
      Klebsiella pneumoniaee strain ATCC 13885	MIC=2 µM
      Proteus mirabilis strain ATCC 25933	MIC=2 µM
      Pseudomonas aeruginosa strain ATCC 15442	MIC=8 µM
      Salmonella typhimurium strain ATCC 14028	MIC=8 µM

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP02478.

DRAMP02478

• • Function

  • Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity).

• • Tissue specificity

  • Expressed by the venom gland.

• ·Literature 1

• • Title

  • Evaluation of an antimicrobial L-amino acid oxidase and peptide derivatives from Bothropoides mattogrosensis pitviper venom.

• • Pubmed ID

  • 22438972

• • Reference

  • PLoS One. 2012;7(3):e33639.

• • Author

  • Okubo BM, Silva ON, Migliolo L, Gomes DG, Porto WF, Batista CL, Ramos CS, Holanda HH, Dias SC, Franco OL, Moreno SE.