• • DRAMP ID

  • DRAMP02764

• • Peptide Name

  • Ponericin-W3 (ants, insects, animals)

• • Source

  • Pachycondyla goeldii (Ponerine ant)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • GIWGTLAKIGIKAVPRVISMLKKKKQ

• • Sequence Length

  • 26

• • UniProt Entry

  • P82425

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal, Antifungal

• • Target Organism

  • • [Ref.11279030]Gram-positive bacteria:

      Target Organism	Activity
      Bacillus cereus CIP 6624a	Inhibition zone = 10mm
      B. megaterium ATCC 9885b	Inhibition zone = 13.5mm
      B. stearothermophilus CIP 675	Inhibition zone = 17mm
      B. subtilis ATCC 6623	Inhibition zone = 13mm
      Enterococcus faecalis CIP 636	Inhibition zone = 8mm
      Lactococcus lactis ssp. cremoris I116	Inhibition zone = 17.5mm
      Streptococcus pyogenes CIP 561	Inhibition zone = 11.5mm
      S. sanguinis CIP 55128	Inhibition zone = 10mm
      Listeria ivanovii LMA 94d	Inhibition zone = 14mm
      Listeria monocytogenes ATCC 15313	Inhibition zone = 11mm
      Micrococcus luteus CIP 5345	Inhibition zone = 11mm
      Staphylococcus aureus CIP 677	Inhibition zone = 13mm
      Staphylococcus aureus LMA	Inhibition zone = 18mm
      S. epidermidis CIP 53134(Inhibition zone = 15mm);	-

    • Gram-negative bacteria:

      Target Organism	Activity
      Escherichia coli	Inhibition zone = 10mm
      Enterobacter cloacae CIP 6085	Inhibition zone = 4mm
      Klebsiella pneumoniae CIP 8291	Inhibition zone = 7.5mm
      Proteus mirabilis LMA TP	no detected
      Salmonella enterica CIP 813	Inhibition zone = 4mm
      Serratia marcescens LMA TP	Inhibition zone = 11mm
      Flavobacterium meningosepticum CIP 6057	no detected
      Pseudomonas aeruginosa CIP A22	Inhibition zone = 18.5mm

• • Hemolytic Activity

  • • [Ref.11279030]1mm in test condition against horse erythrocytes (A 12-ml sample of blood agar medium was supplemented with 1 ml of sheep or horse erythrocytes. Wells 5 mm in diameter were filled with 20 μl of the peptide solution and placed overnight at 4℃ to allow the diffusion of the hemolytic agent)

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP02764.

DRAMP02764

• • Function

  • Broad spectrum of activity against both Gram-positive and Gram-negative bacteria and S.cerevisiae. Has insecticidal and hemolytic activities.

• • Tissue specificity

  • Expressed by the venom gland.

• ·Literature 1

• • Title

  • Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii.

• • Pubmed ID

  • 11279030

• • Reference

  • J. Biol. Chem. 2001; 276: 17823-17829.

• • Author

  • Orivel J, Redeker V, Le Caer JP, Krier F, Revol-Junelles AM, Longeon A, Chaffotte A, Dejean A, Rossier J.