General Information

    • DRAMP ID

    • DRAMP03090

    • Peptide Name

    • Drosophila cecropin B (CecB; Insects, animals)

    • Source

    • Drosophila melanogaster (Fruit fly)

    • Family

    • Belongs to the cecropin family

    • Gene

    • CecB

    • Sequence

    • GWLRKLGKKIERIGQHTRDASIQVLGIAQQAANVAATAR

    • Sequence Length

    • 39

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli D21MIC=1.8 µM
        Enterobacter cloacae b12MIC=1.0 µM
        Pseudomonas aeruginosa OT97 (MIC=4.2 µM);-
      • Gram-positive bacteria:
        Target OrganismActivity
        Bacillus megatherium Bm11MIC=3.7 µM
        Bacillus subtilis BsllMIC=3.2 µM
        Micrococcus luteus MI11MIC=59 µM

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03090 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03090.

Physicochemical Information

    • Formula

    • C184H314N62O52

    • Absent Amino Acids

    • CFMPY

    • Common Amino Acids

    • A

    • Mass

    • 4226.9

    • PI

    • 11.57

    • Basic Residues

    • 8

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 17

    • Net Charge

    • +6

    • Boman Index

    • -72.58

    • Hydrophobicity

    • -0.3

    • Aliphatic Index

    • 102.82

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 144.74

    • Polar Residues

    • 8

DRAMP03090

DRAMP03090 chydropathy plot

Comments Information

    • Induced as part of the humoral response to a bacterial invasion. Transcripts appear within one hour after injection of bacteria into the hemocoel, reach a maximum after 2-6 hours and have almost disappeared after 24 hours. Similar response is seen when flies ingest bacteria present in their food. [Ref.1]

Literature Information

  • ·Literature 1

    • Title

    • The immune response in Drosophila: pattern of cecropin expression and biological activity.

    • Reference

    • EMBO J. 1990 Sep;9(9):2969-2976.

    • Author

    • Samakovlis C, Kimbrell DA, Kylsten P, Engström A, Hultmark D.
  • ·Literature 2

    • Title

    • The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection.

    • Reference

    • EMBO J. 1990 Jan;9(1):217-224.

    • Author

    • Kylsten P, Samakovlis C, Hultmark D.