• DRAMP ID

    • DRAMP03113
    • Peptide Name

    • SK84 (Gly-rich; Insects, animals)
    • Source

    • Drosophila virilis (Fruit fly)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • SQLGDLGSGAGQGGGGGGSIRAAGGAFGKLEAAREEEFFYKKQKEQLERLKNDQIHQAEFHHQQIKEHEEAIQRHKDFLNNLHK
    • Sequence Length

    • 84
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal, Antiviral
    • Target Organism

      • [Ref.19799950]Gram-positive bacteria: Bacillus thuringiensis ATCC 1041 (MIC=4 µM), B. subtilis ATCC 9372 (MIC=8 µM), Staphylococcus aureus ATCC 6538 (MIC=8 µM).
    • Hemolytic Activity

      • [Ref.19799950]0.01% hemolytic activity at 100 μM against human red blood cells
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Free
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03113 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C406H632N128O127
    • Absent Amino Acids

    • CMPTVW
    • Common Amino Acids

    • G
    • Mass

    • 9338.27
    • PI

    • 6.57
    • Basic Residues

    • 18
    • Acidic Residues

    • 13
    • Hydrophobic Residues

    • 24
    • Net Charge

    • +5
    • Boman Index

    • -210.7
    • Hydrophobicity

    • -1.093
    • Aliphatic Index

    • 60.6
    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1490
    • Absorbance 280nm

    • 17.95
    • Polar Residues

    • 20

DRAMP03113

DRAMP03113 chydropathy plot
    • Function

    • SK84 displays antibacterial activity against the tested Gram-positive bacteria (B. subtilis, Bacillus thuringiensis and Staphylococcus aureus), but had no effect on Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli) and fungi (Saccharomyces cerevisiae, Candida albicans). Has weak hemolytic activity.
  • ·Literature 1
    • Title

    • Isolation, characterization and anti-cancer activity of SK84, a novel glycine-rich antimicrobial peptide from Drosophila virilis.
    • Reference

    • Peptides. 2010 Jan;31(1):44-50.
    • Author

    • Lu J, Chen ZW.