General Information
-
DRAMP ID
- DRAMP03113
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Peptide Name
- SK84 (Gly-rich; Insects, animals)
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Source
- Drosophila virilis (Fruit fly)
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Family
- Not found
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Gene
- Not found
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Sequence
- SQLGDLGSGAGQGGGGGGSIRAAGGAFGKLEAAREEEFFYKKQKEQLERLKNDQIHQAEFHHQQIKEHEEAIQRHKDFLNNLHK
-
Sequence Length
- 84
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UniProt Entry
- No entry found
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Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Antifungal, Antiviral
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Target Organism
-
- [Ref.19799950]Gram-positive bacteria: Bacillus thuringiensis ATCC 1041 (MIC=4 µM), B. subtilis ATCC 9372 (MIC=8 µM), Staphylococcus aureus ATCC 6538 (MIC=8 µM).
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Hemolytic Activity
-
- [Ref.19799950]0.01% hemolytic activity at 100 μM against human red blood cells
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
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N-terminal Modification
- Free
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C-terminal Modification
- Free
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Nonterminal Modifications and Unusual Amino Acids
- Free
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Stereochemistry
- L
-
Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP03113_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C406H632N128O127
Absent Amino Acids
- CMPTVW
Common Amino Acids
- G
Mass
- 9338.27
PI
- 6.57
Basic Residues
- 18
Acidic Residues
- 13
Hydrophobic Residues
- 24
Net Charge
- +5
-
Boman Index
- -210.7
Hydrophobicity
- -1.093
Aliphatic Index
- 60.6
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1490
Absorbance 280nm
- 17.95
Polar Residues
- 20
DRAMP03113
Comments Information
Function
- SK84 displays antibacterial activity against the tested Gram-positive bacteria (B. subtilis, Bacillus thuringiensis and Staphylococcus aureus), but had no effect on Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli) and fungi (Saccharomyces cerevisiae, Candida albicans). Has weak hemolytic activity.
Literature Information
- ·Literature 1
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Title
- Isolation, characterization and anti-cancer activity of SK84, a novel glycine-rich antimicrobial peptide from Drosophila virilis.
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Pubmed ID
- 19799950
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Reference
- Peptides. 2010 Jan;31(1):44-50.
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Author
- Lu J, Chen ZW.