General Information

    • DRAMP ID

    • DRAMP03517

    • Peptide Name

    • Moricin-like peptide C3 (Gm-mlpC3; Insects, animals; Predicted)

    • Source

    • Galleria mellonella (Greater wax moth)

    • Family

    • Not found

    • Gene

    • mor

    • Sequence

    • KVPIGAIKKGGKIIKKGLGVIGAAGTAHEVYSHVKNRQ

    • Sequence Length

    • 38

    • Protein Existence

    • Predicted

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)C(C)C)[C@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C)C(C)C)[C@@H](C)O)[C@H](C)CC)C(C)C)[C@H](C)CC)[C@H](C)CC

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacterium:
        Target OrganismActivity
        Escherichia coli (MIC=100 µM);-
      • Gram-positive bacterium:
        Target OrganismActivity
        Micrococcus luteusMIC=100 µM
      • Fungi:
        Target OrganismActivity
        Fusarium graminearum sporesMIC=10 µM
        Fusarium oxysporum sporesMIC=100 µM

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP03517.

Physicochemical Information

    • Formula

    • C177H304N54O46

    • Absent Amino Acids

    • CDFMW

    • Common Amino Acids

    • GK

    • Mass

    • 3924.69

    • PI

    • 10.47

    • Basic Residues

    • 10

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +9

    • Boman Index

    • -28.69

    • Hydrophobicity

    • -0.147

    • Aliphatic Index

    • 102.63

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 40.27

    • Polar Residues

    • 11

DRAMP03517

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • The discovery and analysis of a diverged family of novel antifungal moricin-like peptides in the wax moth Galleria mellonella.

    • Reference

    • Insect Biochem Mol Biol. 2008;38:201-212.

    • Author

    • Brown SE, Howard A, Kasprzak AB, Gordon KH, East PD.