General Information

    • DRAMP ID

    • DRAMP03702

    • Peptide Name

    • Mucroporin (Antimicrobial peptide 36.21; Arthropods, animals)

    • Source

    • Lychas mucronatus (Chinese swimming scorpion)

    • Family

    • Belongs to the short cationic antimicrobial peptide family

    • Gene

    • Not found

    • Sequence

    • LFGLIPSLIGGLVSAFK

    • Sequence Length

    • 17

    • Protein Existence

    • Protein level

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(C)C)[C@H](C)CC)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O)C(C)C

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli AB94012MIC>100 µg/ml
        Pseudomonas aeruginosa AB93066 (MIC>100 µg/ml);-
      • Gram-positive bacteria:
        Target OrganismActivity
        Bacillus thuringiensis AB92037MIC=25 µg/ml
        Bacillus subtilis AB91021MIC=50 µg/ml
        Staphylococcus aureus AB94004MIC=25 µg/ml
        Methicillin-resistant coagulase-negative S. aureusMIC=25 µg/ml

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP03702.

Physicochemical Information

    • Formula

    • C85H138N18O20

    • Absent Amino Acids

    • CDEHMNQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 1732.14

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +1

    • Boman Index

    • 31.8

    • Hydrophobicity

    • 1.618

    • Aliphatic Index

    • 160.59

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP03702

Comments Information

    • Function

    • Function

    • Tissue specificity

    • Expressed by the venom gland.

    • Miscellaneous

    • Minimum inhibitory concentrations (MIC) for Mucroporin-1 analog are the following

Literature Information

  • ·Literature 1

    • Title

    • Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components.

    • Reference

    • BMC Genomics. 2010 Jul 28;11:452.

    • Author

    • Ruiming Z, Yibao M, Yawen H, Zhiyong D, Yingliang W, Zhijian C, Wenxin L.
  • ·Literature 2

    • Title

    • Mucroporin, the first cationic host defense peptide from the venom of Lychas mucronatus.

    • Reference

    • Antimicrob Agents Chemother. 2008 Nov;52(11):3967-3972.

    • Author

    • Dai C, Ma Y, Zhao Z, Zhao R, Wang Q, Wu Y, Cao Z, Li W.