General Information

    • DRAMP ID

    • DRAMP03742

    • Peptide Name

    • Ponericin-W-like 32.2 (Arthropods, animals)

    • Source

    • Lychas mucronatus (Chinese swimming scorpion)

    • Family

    • Belongs to the ponericin-W family

    • Gene

    • Not found

    • Sequence

    • IFGSLFSLGSKLLPTVFKLFSRKKQ

    • Sequence Length

    • 25

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Insecticidal

    • Target Organism

    • [Swiss_Prot Entry P0CI92]Broad spectrum of activity against both Gram-positive and Gram-negative bacteria and S.cerevisiae

    • Hemolytic Activity

      • [Swiss_Prot Entry P0CI92]has hemolytic activities

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03742 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03742.

Physicochemical Information

    • Formula

    • C137H221N33O32

    • Absent Amino Acids

    • ACDEHMNWY

    • Common Amino Acids

    • L

    • Mass

    • 2842.46

    • PI

    • 11.33

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +5

    • Boman Index

    • -11.47

    • Hydrophobicity

    • 0.36

    • Aliphatic Index

    • 105.2

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 7

DRAMP03742

DRAMP03742 chydropathy plot

Comments Information

    • Function

    • Broad spectrum of activity against both Gram-positive and Gram-negative bacteria and S.cerevisiae. Has insecticidal and hemolytic activities (By similarity).

    • Tissue specificity

    • Expressed by the venom gland.

Literature Information

  • ·Literature 1

    • Title

    • Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components.

    • Reference

    • BMC Genomics. 2010 Jul 28;11:452.

    • Author

    • Ruiming Z, Yibao M, Yawen H, Zhiyong D, Yingliang W, Zhijian C, Wenxin L.