General Information

    • DRAMP ID

    • DRAMP03775

    • Peptide Name

    • UyCT2 (Arthropods, animals)

    • Source

    • Urodacus yaschenkoi (Scorpion)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FWGKLWEGVKNAI

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.23182832]Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli ATCC 25922MIC=25 µM
        Pseudomonas aeruginosa ATCC 9027MIC=40 µM

    • Hemolytic Activity

      • [Ref.23182832]3% hemolytic activity at 12.5 μM, 6% hemolytic activity at 25 μM, 5% hemolytic activity at 50 μM, 35% hemolytic activity at 100 μM against human erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03775 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03775.

Physicochemical Information

    • Formula

    • C76H110N18O17

    • Absent Amino Acids

    • CDHMPQRSTY

    • Common Amino Acids

    • GKW

    • Mass

    • 1547.82

    • PI

    • 8.59

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +1

    • Boman Index

    • 0.66

    • Hydrophobicity

    • -0.023

    • Aliphatic Index

    • 90

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 916.67

    • Polar Residues

    • 3

DRAMP03775

Comments Information

    • Function

    • Shows minimum inhibitory concentration against Gram-positive and Gram-negative bacteria. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity.

    • Reference

    • Toxicon. 2013 Mar 1;63:44-54.

    • Author

    • Luna-Ramírez K, Quintero-Hernández V, Vargas-Jaimes L, Batista CV, Winkel KD, Possani LD.