• • DRAMP ID

  • DRAMP03775

• • Peptide Name

  • UyCT2 (Arthropods, animals)

• • Source

  • Urodacus yaschenkoi (Scorpion)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • FWGKLWEGVKNAI

• • Sequence Length

  • 13

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • SMILES

  • CC[C@@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(N)=O

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram-

• • Target Organism

  • • [Ref.23182832]Gram-negative bacteria:

      Target Organism	Activity
      Escherichia coli ATCC 25922	MIC=25 µM
      Pseudomonas aeruginosa ATCC 9027	MIC=40 µM

• • Hemolytic Activity

  • • [Ref.23182832]3% hemolytic activity at 12.5 μM, 6% hemolytic activity at 25 μM, 5% hemolytic activity at 50 μM, 35% hemolytic activity at 100 μM against human erythrocytes

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • Free

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • PDB ID

• Predicted Structure

• There is no predicted structure for DRAMP03775.

DRAMP03775

• • Function

  • Shows minimum inhibitory concentration against Gram-positive and Gram-negative bacteria. Has hemolytic activity.

• ·Literature 1

• • Title

  • Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity.

• • Pubmed ID

  • 23182832

• • Reference

  • Toxicon. 2013 Mar 1;63:44-54.

• • Author

  • Luna-Ramírez K, Quintero-Hernández V, Vargas-Jaimes L, Batista CV, Winkel KD, Possani LD.