General Information

    • DRAMP ID

    • DRAMP03926

    • Peptide Name

    • Cecropin B (1-7)-melittin (4-11)hybrid peptide (CBM)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GWLRKLGAVLKVLTT

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • [Ref.20111863]Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Bacillus subtilis, Bacillus thuringiensis, Salmonella derby.

    • Hemolytic Activity

      • [Ref.20111863]0.05% hemolytic activity at 5 mg/kg, 0.14% hemolytic activity at 10 mg/kg in vivo

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03926 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03926.

Physicochemical Information

    • Formula

    • C78H135N21O18

    • Absent Amino Acids

    • CDEFHIMNPQSY

    • Common Amino Acids

    • L

    • Mass

    • 1655.06

    • PI

    • 11.17

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +3

    • Boman Index

    • 2.62

    • Hydrophobicity

    • 0.667

    • Aliphatic Index

    • 149.33

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 392.86

    • Polar Residues

    • 4

DRAMP03926

Comments Information

    • Function

    • The hemolytic assays indicated CBM had no hemolytic in vivo and in vitro.

Literature Information

  • ·Literature 1

    • Title

    • Design, recombinant expression, and antibacterial activity of the cecropins-melittin hybrid antimicrobial peptides.

    • Reference

    • Curr Microbiol. 2010 Sep;61(3):169-175.

    • Author

    • Cao Y, Yu RQ, Liu Y, Zhou HX, Song LL, Cao Y, Qiao DR.