General Information

    • DRAMP ID

    • DRAMP18663

    • Peptide Name

    • Brevinin 18 (Brevinin-1E truncated peptide 18; Frogs, amphibians, animals)

    • Source

    • Rana esculenta

    • Family

    • Derived from the peptide Brevinin-1E

    • Gene

    • Not found

    • Sequence

    • GLAANFLPKIFCKITRKC

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anitifungal, Anti-Gram-

    • Target Organism

      • [Ref.9748603]Gram-positive bacteria:
        Target OrganismActivity
        Staphylococcus aureus ATCC 6538MIC=25 μg/ml
        Methicillin resistant Staphylococcus aureusMIC=100 μg/ml
        Micrococcus luteus ATCC 9341 (MIC=12.5 μg/ml);-
      • Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli ATCC 2592MIC=25 μg/ml
        Pseudomonas aeruginosa ATCC 9027 (MIC=12.5 μg/ml);-
      • Fungus:
        Target OrganismActivity
        Candida albicans ATCC 36232MIC=25 μg/ml

    • Hemolytic Activity

      • [Ref.9748603]HD50=146 μg/ml(oxidized); HD50=230 μg/ml(reduced) against mouse red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18663 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18663.

Physicochemical Information

    • Formula

    • C93H155N25O21S2

    • Absent Amino Acids

    • DEHMQSVWY

    • Common Amino Acids

    • K

    • Mass

    • 2023.53

    • PI

    • 9.85

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +4

    • Boman Index

    • -802

    • Hydrophobicity

    • 0.467

    • Aliphatic Index

    • 97.78

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 7.35

    • Polar Residues

    • 5

DRAMP18663

DRAMP18663 chydropathy plot

Comments Information

    • Function

    • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Structure-activity analysis of brevinin 1E amide, an antimicrobial peptide from Rana esculenta.

    • Reference

    • Biochim Biophys Acta. 1998 Sep 8;1387(1-2):239-48.

    • Author

    • Kwon MY, Hong SY, Lee KH.