• • DRAMP ID

  • DRAMP18666

• • Peptide Name

  • P1 (Pilosulin-1 1-20; Ant, insects, arthropods, invertebrates, animals)

• • Source

  • Myrmecia pilosula (Jumper ant)

• • Family

  • Derived from the peptide Pilosulin-1, Belongs to the pilosulin family.

• • Gene

  • Not found

• • Sequence

  • GLGSVFGRLARILGRVIPKV

• • Sequence Length

  • 20

• • UniProt Entry

  • Q07932

• • Protein Existence

  • Protein level

• • SMILES

  • Not available

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anitifungal, Anti-Gram-

• • Target Organism

  • • [Ref.15639237]Gram-positive bacteria:

      Target Organism	Activity
      Staphylococcus aureus 710A	MIC=4 μM
      Bacillus megaterium BM11	MIC=2 μM

    • Gram-negative bacteria:

      Target Organism	Activity
      Escherichia coli ML-35	MIC=2 μM
      Pseudomonas aeruginosa ATCC27853	MIC=8 μM
      Salmonella typhimurium ATCC14028	MIC=8 μM

    • Drug resistant clinical isolates:

      Target Organism	Activity
      Staphylococcus simulans 22	MIC=2 μM
      Micrococcus luteus	MIC=0.5 μM
      Enterococcus spp. I-11305b	MIC=2 μM
      Enterococcus spp. I-11054	MIC=2 μM
      Staphylococcus haemolyticus I-10925	MIC=2 μM
      Staphylococcus epidermidis LT1324	MIC=2 μM
      Staphylococcus aureus 5185	MIC=2 μM
      Staphylococcus aureus I-11574	MIC=2 μM
      Staphylococcus aureus LT1338	MIC=3 μM
      Staphylococcus aureus T1334	MIC=1.5 μM
      Citrobacter freundii I-11090	MIC=2 μM
      Klebsiella pneumoniae I-10910	MIC=2 μM
      Escherichia coli I-11276b	MIC=4 μM
      Escherichia coli O-19592	MIC=2 μM
      Stenotrophomonas maltophilia O-16451	MIC=2 μM
      Stenotrophomonas maltophilia I-10717	MIC=2 μM
      Pseudomonas aeruginosa 4991	MIC=4 μM
      Pseudomonas aeruginosa I-10968	MIC=4 μM
      Candida albicans I-11301	MIC=4 μM

• • Hemolytic Activity

  • • [Ref.15639237]20% hemolysis at 10μM, 100% hemolysis at 100μM against human red blood cells

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Alpha helix

• • Structure Description

  • Not found

• • PDB ID

  • 5X3L resolved by NMR.

• Predicted Structure

• Please click DRAMP18666_predicted_structure.pdb to download.

DRAMP18666

• • Function

  • Has strong cytotoxic and hemolytic activities. Is more potent against mononuclear leukocytes than against granulocytes. Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Adopts an alpha-helical structure.

• • Allergenic properties

  • Causes an allergic reaction in human. Binds to IgE.

• ·Literature 1

• • Title

  • Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin.

• • Pubmed ID

  • 15639237

• • Reference

  • Arch Biochem Biophys. 2005 Feb 15;434(2):358-64.

• • Author

  • Zelezetsky I, Pag U, Antcheva N, Sahl HG, Tossi A.