General Information

    • DRAMP ID

    • DRAMP18719

    • Peptide Name

    • SAAP fraction 3 (Surfactant-associated anionic peptides; Asp-rich; sheep, ruminant, mammals, animals)

    • Source

    • Ovis aries

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DDDDDDD

    • Sequence Length

    • 7

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.8552650] Gram-positive bacteria:
        Target OrganismActivity
        Staphylococcus aureus ATCC 29213MBC50=1.21 mM in Zn-saline
        Streptococcus faecalis ATCC 29213 (MBC50=1.39 mM in Zn-saline);-
      • Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli ATCC 12795MBC50=0.64 mM in Zn-saline
        Klebsiella pneumoniae ATCC 10031MBC50=0.62 mM in Zn-saline
        Pasteurella haemolyticaMBC50=0.02 mM in Zn-saline, MBC50=8.52 mM in Test buffer; Peptide/surfactant mixture MBC50=0.01 mM in Zn-saline, MBC50=4.43 mM in Test buffer; Peptide/serum mixture MBC50=0.02 mM in Zn-saline, MBC50=4.95 mM in Test buffer; Peptide/surfactant/serum mixture MBC50=0.03 mM in Zn-saline, MBC50=2.79 mM in Test buffer

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C28H37N7O22

    • Absent Amino Acids

    • ACEFGHIKLMNPQRSTV

    • Common Amino Acids

    • D

    • Mass

    • 823.64

    • PI

    • 3.12

    • Basic Residues

    • 0

    • Acidic Residues

    • 7

    • Hydrophobic Residues

    • 0

    • Net Charge

    • -7

    • Boman Index

    • -6104

    • Hydrophobicity

    • -3.5

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP18719

Comments Information

    • Function

    • Antibacterial activity against Gram positive and negative bacteria. No amidation at the C-terminus

Literature Information

  • ·Literature 1

    • Title

    • Isolation of an ovine pulmonary surfactant-associated anionic peptide bactericidal for Pasteurella haemolytica.

    • Reference

    • Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):412-6.

    • Author

    • Brogden KA, de Lucca AJ, Bland J, Elliott S.