General Information

    • DRAMP ID

    • DRAMP20762

    • Peptide Name

    • Halocin S8 (HalS8, Halocin-S8; Microhalocin, Archaeocin, Bacteriocin, Archaea, Euryarchaeota, Prokaryotes)

    • Source

    • Haloarchaeon S8a

    • Family

    • Not found

    • Gene

    • halS8

    • Sequence

    • SDCNINSNTAADVILCFNQVGSCALCSPTLVGGPVP

    • Sequence Length

    • 36

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

      • [Ref.11114928] Archaea: Sulfolobus solfataricus (Inhibition Zone=4mm)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20762 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20762.

Physicochemical Information

    • Formula

    • C150H243N41O52S4

    • Absent Amino Acids

    • EHKMRWY

    • Common Amino Acids

    • CNSV

    • Mass

    • 3581.06

    • PI

    • 3.56

    • Basic Residues

    • 0

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 16

    • Net Charge

    • -2

    • Boman Index

    • 0.31

    • Hydrophobicity

    • 0.006

    • Aliphatic Index

    • 94.72

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 250

    • Absorbance 280nm

    • 7.14

    • Polar Residues

    • 18

DRAMP20762

DRAMP20762 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against the haloarchaeons H.salinarium NRC817, Halobacterium GRB and H.gibbonsii.

    • Miscellaneous

    • Halocin-S8 is quite robust, as it can be desalted, boiled, subjected to organic solvents, and stored at 4 degrees Celsius for extended periods without losing activity.

Literature Information

  • ·Literature 1

    • Title

    • Halocin S8, a 36-Amino-Acid Microhalocin from the Haloarchaeal Strain S8a.

    • Reference

    • J Bacteriol. 2000 Sep;182(17):4951-8.

    • Author

    • Lance B. Price and Richard F. Shand
  • ·Literature 2

    • Title

    • Secreted euryarchaeal microhalocins kill hyperthermophilic crenarchaea.

    • Reference

    • J Bacteriol. 2001 Jan;183(1):287-91.

    • Author

    • Haseltine C, Hill T, Montalvo-Rodriguez R, Kemper SK, Shand RF, Blum P.