General Information

    • DRAMP ID

    • DRAMP20764

    • Peptide Name

    • Halocin R1 (HalR1, Halocin-R1; Microhalocins, Archaeocin, Bacteriocin, Archaea, Euryarchaeota, Prokaryotes)

    • Source

    • Halobacterium sp. GN101

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • LQSNININTAAAVILIFNQVQVGALCAPTPVSGGGPVP

    • Sequence Length

    • 38

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

      • [Ref.11114928] Archaea: Sulfolobus solfataricus (Inhibition Zone=7mm)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20764 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20764.

Physicochemical Information

    • Formula

    • C167H275N45O50S

    • Absent Amino Acids

    • DEHKMRWY

    • Common Amino Acids

    • AV

    • Mass

    • 3745.35

    • PI

    • 5.52

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 22

    • Net Charge

    • 0

    • Boman Index

    • -0.44

    • Hydrophobicity

    • 0.008

    • Aliphatic Index

    • 123.16

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 16

DRAMP20764

DRAMP20764 chydropathy plot

Comments Information

    • Function

    • HalR1 is a microhalocin ( 38 amino acids ), and even more intriguing, HalR1 is 63% identical and 71% similar to HalS8

    • (identical residues in capitals ) . HalR1 is not cationic like typical bacteriocins and eucaryocins, it will be interesting to discover their mechanisms of action.

Literature Information

  • ·Literature 1

    • Title

    • Halocins and sulfolobicins: the emerging story of archaeal protein and peptide antibiotics.

    • Reference

    • J Ind Microbiol Biotechnol. 2002 Jan;28(1):23-31.

    • Author

    • O'Connor EM, Shand RF.
  • ·Literature 2

    • Title

    • Secreted euryarchaeal microhalocins kill hyperthermophilic crenarchaea.

    • Reference

    • J Bacteriol. 2001 Jan;183(1):287-91.

    • Author

    • Haseltine C, Hill T, Montalvo-Rodriguez R, Kemper SK, Shand RF, Blum P.