General Information

    • DRAMP ID

    • DRAMP20772

    • Peptide Name

    • cPcAMP1/26 (ciliate, Protists)

    • Source

    • Paramecium caudatum

    • Family

    • Not found

    • Gene

    • Pcamp1

    • Sequence

    • PPHKKKLAVYPVFLFYLFLSWFSLIV

    • Sequence Length

    • 26

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

    • [Ref.26883426] cPcAMP1/26 is capable of markedly killing A. hydrophila and S. aureus (p < 0.05), with the bactericidal rates being 27.7%, 31.7% and 40.1% as well as 34.4%, 47.4% and 49.2%, respectively

    • Hemolytic Activity

      • [Ref.26883426] cPcAMP1/26 showed little hemolytic activity towards human erythrocytes at 100 μg/ml

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP20772 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP20772.

Physicochemical Information

    • Formula

    • C164H238N32O31

    • Absent Amino Acids

    • CDEGMNQRT

    • Common Amino Acids

    • L

    • Mass

    • 3153.89

    • PI

    • 9.84

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 15

    • Net Charge

    • +4

    • Boman Index

    • 2931

    • Hydrophobicity

    • 0.935

    • Aliphatic Index

    • 127.31

    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?

    • Extinction Coefficient Cystines

    • 8480

    • Absorbance 280nm

    • 339.2

    • Polar Residues

    • 4

DRAMP20772

DRAMP20772 chydropathy plot

Comments Information

    • Function

    • cPcAMP1/26 is capable of markedly killing A. hydrophila and S. aureus (p < 0.05)

Literature Information

  • ·Literature 1

    • Title

    • Identification and functional characterization of an uncharacterized antimicrobial peptide from a ciliate Paramecium caudatum.

    • Reference

    • Dev Comp Immunol. 2016 Jul;60:53-65.

    • Author

    • Cui P, Dong Y, Li Z, Zhang Y, Zhang S.