• • DRAMP ID

  • DRAMP20781

• • Peptide Name

  • Panurgine 1(bees,insects,animals)

• • Source

  • Panurgus calcaratus(communal bee)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • LNWGAILKHIIK

• • Sequence Length

  • 12

• • UniProt Entry

  • C0HL84

• • Protein Existence

  • Not found

• • SMILES

  • CC[C@@H](C)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(N)=O)[C@H](C)CC)[C@H](C)CC

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.23483218] Gram-negative bacteria:

      Target Organism	Activity
      Escherichia coli	MIC=3.7μM
      Pseudomonas aeruginosa	MIC=51.7μM

    • Gram-positive bacteria:

      Target Organism	Activity
      Micrococcus luteus	MIC=1.5μM
      Bacillus subtilis	MIC=1.3μM
      Staphylococcus aureus	MIC=10.6μM

    • Yeast:

      Target Organism	Activity
      Candida albicans	MIC=7.3μM

• • Hemolytic Activity

  • • [Ref.23483218] LC50=119μM against rat red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP20781_predicted_structure.pdb to download.

DRAMP20781

• • Function

  • Exhibits antimicrobial activity against the Gram-positive and Gram-negative bacteria, antifungal activity, and low hemolytic activity against human erythrocytes.

• ·Literature 1

• • Title

  • Panurgines, novel antimicrobial peptides from the venom of communal bee Panurgus calcaratus (Hymenoptera: Andrenidae).

• • Pubmed ID

  • 23483218

• • Reference

  • Amino Acids. 2013 Jul;45(1):143-57.

• • Author

  • Čujová S, Slaninová J, Monincová L, Fuμík V, Bednárová L, μtokrová J, Hovorka O, Voburka Z, Straka J, μeμovskμ V.