General Information

    • DRAMP ID

    • DRAMP20783

    • Peptide Name

    • Pleurain-M1 (Frogs,amphibians,animals)

    • Source

    • Nidirana pleuraden (Yunnan pond frog)

    • Family

    • Belongs to the frog skin active peptide (FSAP) family. Pleurain subfamily.

    • Gene

    • Not found

    • Sequence

    • GLLDSVKEGLKKVAGQLLDTLKCKISGCTPA

    • Sequence Length

    • 31

    • Protein Existence

    • Not found

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CC[C@H](NC(=O)[C@@H](NC(=O)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)O)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.19028675] Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli (MIC=6.3 μg/ml);-
      • Gram-positive bacteria:
        Target OrganismActivity
        Staphylococcus aureusMIC=6.3 μg/ml
        Bacillus subtilis (MIC=25 μg/ml);-
      • Yeast:
        Target OrganismActivity
        Candida albicansMIC=12.5 μg/ml

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP20783.

Physicochemical Information

    • Formula

    • C139H245N37O43S2

    • Absent Amino Acids

    • FHMNRWY

    • Common Amino Acids

    • L

    • Mass

    • 3186.82

    • PI

    • 8.79

    • Basic Residues

    • 5

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +2

    • Boman Index

    • -1702

    • Hydrophobicity

    • 0.148

    • Aliphatic Index

    • 113.23

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 4.17

    • Polar Residues

    • 10

DRAMP20783

Comments Information

    • Function

    • Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi.

Literature Information

  • ·Literature 1

    • Title

    • Antioxidant peptidomics reveals novel skin antioxidant system.

    • Reference

    • Mol Cell Proteomics. 2009 Mar;8(3):571-83.

    • Author

    • Yang H, Wang X, Liu X, Wu J, Liu C, Gong W, Zhao Z, Hong J, Lin D, Wang Y, Lai R.