General Information
-
DRAMP ID
- DRAMP20783
-
Peptide Name
- Pleurain-M1 (Frogs,amphibians,animals)
-
Source
- Nidirana pleuraden (Yunnan pond frog)
-
Family
- Belongs to the frog skin active peptide (FSAP) family. Pleurain subfamily.
-
Gene
- Not found
-
Sequence
- GLLDSVKEGLKKVAGQLLDTLKCKISGCTPA
-
Sequence Length
- 31
-
UniProt Entry
- B5L1L3
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Ref.19028675] Gram-negative bacteria: Escherichia coli (MIC=6.3 μg/ml);
- Gram-positive bacteria: Staphylococcus aureus (MIC=6.3 μg/ml), Bacillus subtilis (MIC=25 μg/ml);
- Yeast: Candida albicans(MIC=12.5 μg/ml).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP20783.
Physicochemical Information
-
Formula
- C139H245N37O43S2
Absent Amino Acids
- FHMNRWY
Common Amino Acids
- L
Mass
- 3186.82
PI
- 8.79
Basic Residues
- 5
Acidic Residues
- 3
Hydrophobic Residues
- 11
Net Charge
- +2
-
Boman Index
- -1702
Hydrophobicity
- 0.148
Aliphatic Index
- 113.23
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 4.17
Polar Residues
- 10
DRAMP20783
Comments Information
Function
- Antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungi.
Literature Information
- ·Literature 1
-
Title
- Antioxidant peptidomics reveals novel skin antioxidant system.
-
Pubmed ID
- 19028675
-
Reference
- Mol Cell Proteomics. 2009 Mar;8(3):571-83.
-
Author
- Yang H, Wang X, Liu X, Wu J, Liu C, Gong W, Zhao Z, Hong J, Lin D, Wang Y, Lai R.