• • DRAMP ID

  • DRAMP20793

• • Peptide Name

  • Maculatin 1.2 (Frog, amphibians, animals)

• • Source

  • Litoria genimaculata (Green-eyed tree frog)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • GLFVGLAKVAAHNNPAIAEHFQA

• • Sequence Length

  • 23

• • UniProt Entry

  • P82067

• • Protein Existence

  • Not found

• • SMILES

  • CC[C@@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(C)C)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(N)=O

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+

• • Target Organism

  • • [Ref.9620615] Gram positive bacteria:

      Target Organism	Activity
      Staphylococcus aureus	MIC=50 μg/ml
      Streptococcus uberis	MIC=6 μg/ml

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

• • Stereochemistry

  • L

• • Structure

  • Helix

• • Structure Description

  • Not found

• • PDB ID

• Predicted Structure

• There is no predicted structure for DRAMP20793.

DRAMP20793

• • Function

  • Antibacterial activity against Staphylococcus aureus and Streptococcus uberis.

• • Tissue specificity

  • Expressed by the skin dorsal glands.

• ·Literature 1

• • Title

  • The maculatin peptide from the skin glands of the tree frog Litoria genimaculata. A comparison of the structures and antibacterial activities of maculatin 1.1 and caerin 1.1

• • Pubmed ID

  • 9620615

• • Reference

  • J. Pept. Sci. 1998 Apr; 4(2): 111-115.

• • Author

  • Rozek T, Waugh RJ, Steinborner ST, Bowie JH, Tyler MJ, Wallace JC.