• • DRAMP ID

  • DRAMP20803

• • Peptide Name

  • moronecidin-like peptide

• • Source

  • Hippocampus comes

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • FFRNLWKGAKAAFRAGHAAWRA

• • Sequence Length

  • 22

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • SMILES

  • CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(N)=O

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.30039186] Gram-positive bacteria:

      Target Organism	Activity
      Staphylococcus aureus ATCC 25923	MIC=3.12 μg/ml
      Staphylococcus epidermidis ATCC 1435	MIC=1.56 μg/ml
      Staphylococcus aureus MRSA (MIC=3.12 μg/ml);	-

    • Gram-negative bacteria:

      Target Organism	Activity
      Escherichia coli ATCC 25922	MIC=6.25 μg/ml
      Pseudomonas aeruginosa ATCC10662	MIC=50 μg/ml
      Acinetobacter baumannii clinical isolate (MIC=6.25 μg/ml);	-

    • Fungi:

      Target Organism	Activity
      Candida albicans clinical isolate	MIC=6.25 μg/ml
      Candida tropicalis clinical isolate	MIC=6.25 μg/ml

• • Hemolytic Activity

  • • [Ref.30039186] 50% hemolysis at 87.5μg/ml,25% hemolysis at 50μg/ml,60% hemolysis at 100μg/ml against human red cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP20803_predicted_structure.pdb to download.

DRAMP20803

• • Function

  • Antibacterial activity against the Gram-positive and Gram-negative bacteria; antifungal activity.

• ·Literature 1

• • Title

  • Identification and Characterization of Novel Antimicrobial Peptide from Hippocampus comes by In Silico and Experimental Studies

• • Pubmed ID

  • 30039186

• • Reference

  • Mar Biotechnol (NY). 2018 Dec;20(6):718-728.

• • Author

  • Mohammadi M, Taheri B, Momenzadeh N, Salarinia R, Nabipour I, Farshadzadeh Z, Bargahi A.