General Information

    • DRAMP ID

    • DRAMP29164

    • Peptide Name

    • EKL0

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGTYEYYVKW

    • Sequence Length

    • 45

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)CC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CC[C@H](NC(=O)[C@H](CCC(=O)N[C@@H](CCSC)C(=O)O)NC(=O)[C@H](CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O)[C@H](C)CC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)N[C@@H](CCC(=O)N[C@H](C(=O)N[C@@H](CCC(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@H](C)CC

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral(SARS-CoV-2)

    • Target Organism

      • [Ref.34367893]Virus:
        Target OrganismActivity
        SARS-CoV-2:Inhibition of Pseudovirus(PsV) infection in Huh-7 cellsIC50=0.583±0.073 μmol/L
        Inhibition of Pseudovirus(PsV) infection in 293T/ACE2 cellsIC50>5 μmol/L
        Inhibition of Pseudovirus(PsV) infection in Caco-2 cellsIC50=0.442±0.037 μmol/L
        inhibition of cell-cell fusionIC50=0.277±0.029 μmol/L

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • liposomes

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C256H392N54O79S

    • Absent Amino Acids

    • CHPR

    • Common Amino Acids

    • E

    • Mass

    • 5522.3

    • PI

    • 4.44

    • Basic Residues

    • 6

    • Acidic Residues

    • 11

    • Hydrophobic Residues

    • 15

    • Net Charge

    • -5

    • Boman Index

    • -7107

    • Hydrophobicity

    • -0.549

    • Aliphatic Index

    • 101.78

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 12950

    • Absorbance 280nm

    • 294.32

    • Polar Residues

    • 11

DRAMP29164

Comments Information

    • The peptide targets a highly conserved target site in HR1 domains in S protein of HCoVs.

Literature Information

  • ·Literature 1

    • Title

    • A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases.

    • Reference

    • Acta Pharm Sin B. 2021 Aug 2.

    • Author

    • Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q.