General Information

    • DRAMP ID

    • DRAMP29186

    • Peptide Name

    • IPB08(SARS-CoV-2-S (1169-1198)-K)

    • Source

    • Synthetic construct

    • Family

    • Belongs to the betacoronaviruses spike protein family.

    • Gene

    • S

    • Sequence

    • ISGINASVVNIQKEIDRLNEVAKNLNESLIK

    • Sequence Length

    • 31

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral(SARS-CoV-2)

    • Target Organism

      • [Ref.32376627]Virus:
      • SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=4.66 ± 1.565 µM),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=1.738 ± 0.898 µM);
      • SARS-CoV:inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC=1.13 ± 0.472 µM);
      • Vesicular Stomatitis Virus (VSV):inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>50 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • liposomes

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Chol

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29186 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29186.

Physicochemical Information

    • Formula

    • C148H257N43O49

    • Absent Amino Acids

    • CFHMPTWY

    • Common Amino Acids

    • IN

    • Mass

    • 3422.93

    • PI

    • 6.26

    • Basic Residues

    • 4

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 13

    • Net Charge

    • 0

    • Boman Index

    • -5362

    • Hydrophobicity

    • -0.126

    • Aliphatic Index

    • 135.16

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 9

DRAMP29186

DRAMP29186 chydropathy plot

Comments Information

    • Mechanism of action

    • The peptide was designed based on HR2 sequence lipopeptide fusion inhibitor,which showed highly potent activities in inhibiting SARS-CoV-2 S protein-mediated cell-cell fusion and pseudovirus transduction. It can also inhibit the SARS-CoV pseudovirus efficiently.

Literature Information

  • ·Literature 1

    • Title

    • Design of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity.

    • Reference

    • J Virol. 2020 Jul 1;94(14):e00635-20.

    • Author

    • Zhu Y, Yu D, Yan H, Chong H, He Y.