General Information

    • DRAMP ID

    • DRAMP29192

    • Peptide Name

    • ACE2 (27-42)(SAP1)

    • Source

    • Synthetic construct

    • Family

    • Belongs to the peptidase M2 family.

    • Gene

    • ACE2

    • Sequence

    • TFLDKFNHEAEDLFYQ

    • Sequence Length

    • 16

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral(SARS-CoV-2)

    • Target Organism

      • [Ref.33356169]Virus:
      • SARS-CoV-2:Inhibition of infection in 293T/ACE2 cells(IC50=2.39±0.20 mM);Inhibition of infection in 293T/ACE2/GFP cells(IC50=3 mM);
      • SARS-CoV:Inhibition of infection in 293T/ACE2 cells(80% inhibition at 3 mM);
      • Vesicular Stomatitis Virus (VSV):No nhibition of infection in 293T/ACE2 cells up to 3 mM;
      • HCoV-NL63:Inhibition of cytopathic effect in LLC-MK2 cells(30% Inhibition at 3 mM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29192 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29192.

Physicochemical Information

    • Formula

    • C94H129N21O29

    • Absent Amino Acids

    • CGIMPRSVW

    • Common Amino Acids

    • F

    • Mass

    • 2017.18

    • PI

    • 4.31

    • Basic Residues

    • 2

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 6

    • Net Charge

    • -2

    • Boman Index

    • -3557

    • Hydrophobicity

    • -0.769

    • Aliphatic Index

    • 55

    • Half Life

      • Mammalian:7.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 99.33

    • Polar Residues

    • 3

DRAMP29192

Comments Information

    • Mechanism of action

    • Inhibiting SARS-CoV-2 infection by disrupting the Spike-ACE2 interaction interface with peptide-based inhibitors.

Literature Information

  • ·Literature 1

    • Title

    • Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2.

    • Reference

    • Bioconjug Chem. 2021 Jan 20;32(1):215-223.

    • Author

    • Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A.