• • DRAMP ID

  • DRAMP29192

• • Peptide Name

  • ACE2 (27-42)(SAP1)

• • Source

  • Synthetic construct

• • Family

  • Belongs to the peptidase M2 family.

• • Gene

  • ACE2

• • Sequence

  • TFLDKFNHEAEDLFYQ

• • Sequence Length

  • 16

• • UniProt Entry

  • Q9BYF1

• • Protein Existence

  • Protein level

• • SMILES

  • CC(C)C[C@H](NC(=O)[C@H](CCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)O)NC(=O)[C@H](CCC(=O)N[C@@H](CC(=O)O)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O

• • Biological Activity

  • Antimicrobial, Antiviral(SARS-CoV-2)

• • Target Organism

  • • [Ref.33356169]Virus:
    • SARS-CoV-2:

      Target Organism	Activity
      Inhibition of infection in 293T/ACE2 cells(IC50=2.39±0.20 mM);Inhibition of infection in 293T/ACE2/GFP cells(IC50=3 mM);	-

    • SARS-CoV:

      Target Organism	Activity
      Inhibition of infection in 293T/ACE2 cells(80% inhibition at 3 mM);	-

    • Vesicular Stomatitis Virus (VSV):

      Target Organism	Activity
      No nhibition of infection in 293T/ACE2 cells up to 3 mM;	-

    • HCoV-NL63: Inhibition of cytopathic effect in LLC-MK2 cells(30% Inhibition at 3 mM).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • PDB ID

• Predicted Structure

• There is no predicted structure for DRAMP29192.

DRAMP29192

• • Mechanism of action

  • Inhibiting SARS-CoV-2 infection by disrupting the Spike-ACE2 interaction interface with peptide-based inhibitors.

• ·Literature 1

• • Title

  • Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2.

• • Pubmed ID

  • 33356169

• • Reference

  • Bioconjug Chem. 2021 Jan 20;32(1):215-223.

• • Author

  • Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A.