General Information

    • DRAMP ID

    • DRAMP29197

    • Peptide Name

    • ACE2 (37-42)(SAP6)

    • Source

    • Synthetic construct

    • Family

    • Belongs to the peptidase M4 family.

    • Gene

    • ACE2

    • Sequence

    • EDLFYQ

    • Sequence Length

    • 6

    • Protein Existence

    • Protein level

    • SMILES

    • CC(C)C[C@H](NC(=O)[C@@H](N)CCC(=O)N[C@@H](CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(=O)O

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral(SARS-CoV-2)

    • Target Organism

      • [Ref.33356169]Virus:
      • SARS-CoV-2:
        Target OrganismActivity
        Inhibition of infection in 293T/ACE2 cells(IC50=1.9±0.14 mM);Inhibition of infection in 293T/ACE2/GFP cellsIC50=3 mM
      • SARS-CoV:
        Target OrganismActivity
        Inhibition of infection in 293T/ACE2 cells85% inhibition at 3 mM
      • Vesicular Stomatitis Virus (VSV):
        Target OrganismActivity
        No nhibition of infection in 293T/ACE2 cells up to 3 mM-
      • HCoV-NL63: Inhibition of cytopathic effect in LLC-MK2 cells(30% Inhibition at 3 mM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C38H51N7O13

    • Absent Amino Acids

    • ACGHIKMNPRSTVW

    • Common Amino Acids

    • DEFLQY

    • Mass

    • 813.86

    • PI

    • 3.67

    • Basic Residues

    • 0

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 2

    • Net Charge

    • -2

    • Boman Index

    • -1331

    • Hydrophobicity

    • -0.867

    • Aliphatic Index

    • 65

    • Half Life

      • Mammalian:1 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 298

    • Polar Residues

    • 1

DRAMP29197

Comments Information

    • Mechanism of action

    • Inhibiting SARS-CoV-2 infection by disrupting the Spike-ACE2 interaction interface with peptide-based inhibitors.

Literature Information

  • ·Literature 1

    • Title

    • Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2.

    • Reference

    • Bioconjug Chem. 2021 Jan 20;32(1):215-223.

    • Author

    • Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A.