General Information

    • DRAMP ID

    • DRAMP29202

    • Peptide Name

    • ATN-161

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • PHSCN

    • Sequence Length

    • 5

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral(SARS-CoV-2)

    • Target Organism

      • [Ref.33102950]Virus:SARS-CoV-2:inhibition of replication In VeroE6 cells(IC50=3.16 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Acylation

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29202 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29202.

Physicochemical Information

    • Formula

    • C21H32N8O8S

    • Absent Amino Acids

    • ADEFGIKLMQRTVWY

    • Common Amino Acids

    • CHNPS

    • Mass

    • 556.59

    • PI

    • 7.12

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 0

    • Net Charge

    • +1

    • Boman Index

    • -1342

    • Hydrophobicity

    • -1.32

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:>20 hour
      • Yeast:>20 hour
      • E.coli:?

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP29202

Comments Information

    • Mechanism of action

    • The peptide inhibits the spike protein interaction with α5β1 integrin and the interaction between α5β1 integrin and ACE2.

Literature Information

  • ·Literature 1

    • Title

    • The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection.

    • Reference

    • JACC Basic Transl Sci. 2021 Jan;6(1):1-8.

    • Author

    • Beddingfield BJ, Iwanaga N, Chapagain PP, Zheng W, Roy CJ, Hu TY, Kolls JK, Bix GJ.