General Information

    • DRAMP ID

    • DRAMP31797

    • Peptide Name

    • Temporin-La

    • Source

    • Temporins family

    • Family

    • Gene

    • Not found

    • Sequence

    • LLRHVVKILEKYL

    • Sequence Length

    • 13

    • Protein Existence

    • Not found

    • SMILES

    • CC[C@@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells:
        Target OrganismActivity
        MEC (24.15Inhibition ratio at 50 µg/ml); HL-7702(L-02) (37.22 Inhibition ratio at 50 µg/ml); A549 (45.62 Inhibition ratio at 50 µg/ml); BGC-823 (48.19 Inhibition ratio at 50 µg/ml); Hep-G2 (50.90 Inhibition ratio at 50 µg/ml); HeLa (52.32 Inhibition ratio at 50 µg/ml); SMMC-7721 (52.77 Inhibition ratio at 50 µg/ml); SW111657.62 Inhibition ratio at 50 µg/ml

    • Hemolytic Activity

      • Showed no hemolytic activity against rabbit erythrocytes and human erythrocytes at 250 µg/ml

    • Cytotoxicity

      • Showed little effects on the proliferation of the 293T human embryonic kidney cell line, MECs, and human lymphomonocytes at concentrations of less than 50 µg/ml

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Stereochemistry

    • L

    • Predicted Structure

    • There is no predicted structure for DRAMP31797.

Physicochemical Information

    • Formula

    • Absent Amino Acids

    • Common Amino Acids

    • Mass

    • 0

    • PI

    • 0

    • Basic Residues

    • Acidic Residues

    • Hydrophobic Residues

    • Net Charge

    • Boman Index

    • 0

    • Hydrophobicity

    • 0

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:
      • Yeast:
      • E.coli:

    • Extinction Coefficient Cystines

    • Absorbance 280nm

    • 0

    • Polar Residues

DRAMP31797

Comments Information

    • A membrane-disturbing action seems to be the major mechanism for cell death

Literature Information

  • ·Literature 1

    • Title

    • Designed synthetic analogs of the α-helical peptide temporin-La with improved antitumor efficacies via charge modification and incorporation of the integrin αvβ3 homing domain

    • Reference

    • J Pept Sci. 2012 Jul;18(7):476-86.

    • Author

    • Diao Y, Han W, Zhao H, Zhu S, Liu X, Feng X, Gu J, Yao C, Liu S, Sun C, Pan F.