General Information

    • DRAMP ID

    • DRAMP20798

    • Peptide Name

    • Lingual antimicrobial peptide (LAP, beta defensin, cattle, ruminant, animals)

    • Source

    • Bos taurus (Bovine)

    • Family

    • Belongs to the beta-defensin family. LAP/TAP subfamily.

    • Gene

    • LAP

    • Sequence

    • QGVRNSQSCRRNKGICVPIRCPGSMRQIGTCLGAQVKCCRRK

    • Sequence Length

    • 42

    • Protein Existence

    • Protein level

    • SMILES

    • CC[C@@H](C)[C@@H]1NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N)CCC(N)=O)C(C)C)CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]3CSSC[C@H](NC1=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@H](C)CC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)O)NC2=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@H](C)CC)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N3

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.7886453] Gram-positive bacterium:
        Target OrganismActivity
        Staphylococcus aureus 29213 (MIC=63-125 μg/ml);-
      • Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli D31MIC=16-32 μg/ml
        Pseudomonas aeruginosa 27853 (MIC=63-125 μg/ml);-
      • Fungi:
        Target OrganismActivity
        Candida albicans 14053MIC=32-63 μg/ml
        Candida tropicalis 13803MIC=16-32 μg/ml

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds between Cys9 and Cys38, Cys16 and Cys31, Cys21 and Cys39.

    • Stereochemistry

    • L

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • PDB ID

    • Predicted Structure

    • There is no predicted structure for DRAMP20798.

Physicochemical Information

    • Formula

    • C186H332N72O53S7

    • Absent Amino Acids

    • DEFHWY

    • Common Amino Acids

    • R

    • Mass

    • 4649.55

    • PI

    • 10.85

    • Basic Residues

    • 10

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +10

    • Boman Index

    • -12096

    • Hydrophobicity

    • -0.569

    • Aliphatic Index

    • 60.24

    • Half Life

      • Mammalian:0.8 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 9.15

    • Polar Residues

    • 17

DRAMP20798

Comments Information

    • Function

    • Shows a broad spectrum of antibacterial and antifungal activities.

    • Tissue specificity

    • In many of the exposed epithelial surfaces including conjunctivae, bronchi, colon, urinary tract and trachea.

    • Developmental stage

    • Not found in fetus.

Literature Information

  • ·Literature 1

    • Title

    • Epithelial antibiotics induced at sites of inflammation.

    • Reference

    • Science. 1995 Mar 17; 267(5204):1645-1648

    • Author

    • Schonwetter BS., Stolzenberg ED., Zasloff MA.