Patent Information

    • DRAMP ID

    • DRAMP04727

    • Sequence

    • KNLRRTIRKIIHIIKKYG

    • Sequence Length

    • 18

    • Sequence Name

    • Sequence 4 from Patent US 20020082195

    • Source

    • Synthetic construct

    • Activity

    • Antimicrobial, Antibacterial

    • Patent Type

    • Patent Application

    • Publication Date

    • 2002-6-27

    • Patent Title

    • Novispirins: antimicrobial peptides.

    • Abstract

    • Novispirin peptides are antimicrobial agents with potent activity against Gram-negative bacteria. The peptides are nonhemolytic, exhibit reduced in vitro cytotoxicity relative to other antimicrobial peptides, and were well-tolerated in vivo after intravenous injection. Novispirins also bind lipopolysaccharide (LPS), a property that may mitigate symptoms associated with Gram-negative bacterial infection. A pharmaceutical composition comprising novispirin as an active agent is administered to a patient suffering from or predisposed to a microbial infection, particularly Gram-negative bacterial infections.