Patent Information

    • DRAMP ID

    • DRAMP28100

    • Sequence

    • ILGTICKLLKSL

    • Sequence Length

    • 12

    • Sequence Name

    • Sequence 100 from Patent WO 2020061306

    • Source

    • Synthetic construct

    • SMILES

    • CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC)[C@@H](C)O

    • Activity

    • Antimicrobial

    • Patent Type

    • Patent Application

    • Publication Date

    • 2020-3-26

    • Patent Title

    • Methods Of Physicochemical-guided Peptide Design And Novel Peptides Derived Therefrom

    • Abstract

    • Described herein are methods of physicochemical-guided peptide design that utilize specific functional determinants to a protein's property of interest. Also described herein are novel synthetic peptide antibiotics that have increased potency and/or decreased toxicity relative to the template peptide from which they were derived, and methods of use thereof in treating microbial infections.