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Sequence Name
- Sequence 1 from Patent WO
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Source
- Synthetic construct
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Patent Type
- Patent Application
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Publication Date
- 2020-2-13
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Patent Title
- Antimicrobial Peptides And Methods Of Making And Using Same
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Abstract
- The present invention provides a new methodology combining MD simulations and database-guided high-throughput screening to rationally design pore forming membrane-active peptides. The present inventive methodology is able to allow tuning of a range of structural and functional properties such as pore size and selectively targeting membranes with specific lipid compositions. The present inventive methods will ultimately allow de novo design of membrane-active peptides for a wide range of biomedical applications, including for example, antimicrobial agents.