Patent Information

    • DRAMP ID

    • DRAMP36350

    • Sequence

    • GLWKSLFKNVGKAAGKAALNAVTDMVNQ

    • Sequence Length

    • 28

    • Sequence Name

    • DMS-PS1

    • Source

    • South America frog Phy l

    • Activity

    • Antimicrobial, Anticancer

    • Patent Type

    • Patent Application

    • Publication Date

    • 2022-8-2

    • Patent Title

    • Anticancer peptide DMS-PS1 of South America frog and application thereof

    • Abstract

    • The invention discloses a rana amurensis frog anticancer peptide DMS-PS1 and application thereof, which can be used in the fields of anticancer drugs and health care products and preparation, wherein rana amurensis frog Phy l lomedusa sauuvagi i is used as a material, a novel natural anticancer peptide DMS-PS1 is obtained by separating from frog skin secretion, open reading frames of the polypeptide consist of 76 amino acids, the polypeptide contains a highly conserved signal peptide consisting of 22 amino acid residues, and acidic amino acids such as rich aspartic acid, glutamic acid and the like, the molecular weight of the polypeptide is 2931.43 daltons, the C end of the polypeptide contains amidation modification, and the polypeptide is amphiphilic cationic peptide with an alpha-helix structure, the invention discloses that the natural anticancer peptide DMS-PS1 shows spectral anticancer activity and shows certain selectivity to prostate cancer cells, researches show that the peptide has antic